15 Historical Pandemics and Diseases Trivia Questions and Answers

We remember what it was like to lockdown and stay home. Can you answer these historical pandemics and diseases trivia questions?

15 Historical Pandemics and Diseases Trivia Questions

1. Which pandemic, caused by the Yersinia pestis bacterium, killed an estimated 25 million people in Europe during the 14th century?
2. What disease, caused by the variola virus, was officially declared eradicated by the World Health Organization in 1980?
3. Which pandemic, originating in the Spanish flu virus H1N1, killed an estimated 50 million people worldwide in 1918-1919?
4. What deadly bacterial infection, transmitted through contaminated water, caused seven global pandemics since the 19th century? –
5. Which disease, caused by Mycobacterium leprae, led to the creation of isolated colonies called leper colonies?
6. What disease, caused by the human immunodeficiency virus (HIV), emerged in the late 20th century and became a global health crisis?
7. Which highly contagious disease, once a leading cause of death among children, was virtually eradicated due to the MMR vaccine?
8. What pandemic, caused by a strain of the H1N1 virus, spread rapidly in 2009 and affected people globally?
9. Which disease, first identified in the 1980s, leads to a breakdown of the immune system, making individuals vulnerable to other infections?
10. Which ancient plague struck the Byzantine Empire in 541–542 AD and is often considered the first recorded pandemic?
11. What mosquito-borne viral disease, known for causing birth defects in babies born to infected mothers, spread rapidly in the Americas in 2015-2016?
12. Which pandemic, caused by a coronavirus, began in 2020 and led to widespread global lockdowns and public health measures?
13. What deadly disease, spread by rats and fleas, caused the Great Plague of London in 1665-1666?
14. Which viral hemorrhagic fever, primarily affecting West Africa, caused a major outbreak in 2014-2016?
15. Which bacterial disease, also known as “consumption,” was a leading cause of death in Europe and America in the 19th century?

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15 Historical Pandemics and Diseases Trivia Questions and Answers

1. Which pandemic, caused by the Yersinia pestis bacterium, killed an estimated 25 million people in Europe during the 14th century? – The Black Death (Bubonic Plague)
2. What disease, caused by the variola virus, was officially declared eradicated by the World Health Organization in 1980? – Smallpox
3. Which pandemic, originating in the Spanish flu virus H1N1, killed an estimated 50 million people worldwide in 1918-1919? – The Spanish Flu
4. What deadly bacterial infection, transmitted through contaminated water, caused seven global pandemics since the 19th century? – Cholera
5. Which disease, caused by Mycobacterium leprae, led to the creation of isolated colonies called leper colonies? – Leprosy
6. What disease, caused by the human immunodeficiency virus (HIV), emerged in the late 20th century and became a global health crisis? – HIV/AIDS
7. Which highly contagious disease, once a leading cause of death among children, was virtually eradicated due to the MMR vaccine? – Measles
8. What pandemic, caused by a strain of the H1N1 virus, spread rapidly in 2009 and affected people globally? – Swine Flu (H1N1)
9. Which disease, first identified in the 1980s, leads to a breakdown of the immune system, making individuals vulnerable to other infections? – HIV/AIDS
10. Which ancient plague struck the Byzantine Empire in 541–542 AD and is often considered the first recorded pandemic? – Plague of Justinian
11. What mosquito-borne viral disease, known for causing birth defects in babies born to infected mothers, spread rapidly in the Americas in 2015-2016? – Zika Virus
12. Which pandemic, caused by a coronavirus, began in 2020 and led to widespread global lockdowns and public health measures? – COVID-19
13. What deadly disease, spread by rats and fleas, caused the Great Plague of London in 1665-1666? – Bubonic Plague
14. Which viral hemorrhagic fever, primarily affecting West Africa, caused a major outbreak in 2014-2016? – Ebola
15. Which bacterial disease, also known as “consumption,” was a leading cause of death in Europe and America in the 19th century? – Tuberculosis (TB)

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